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The main difference between a Python crypto arbitrage trading bot and a manual arbitrage trading strategy is that the trading bot executes trades automatically, while the manual option requires the manual execution of trades based on the user's analysis of the markets. Additionally, the bot may provide information such as price changes and market patterns in an automated fashion, while a manual system requires the user to do their own research and analysis. The automated bot is also more efficient and accurate in its trades, as much of the trading analysis occurs in the background rather than having to be done by the traders themselves. Finally, a trading bot is generally more cost-effective than manual trading, as there are typically lower commission fees to consider.